⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22016204 | 0.71 | KDM5A (0.38) | — | |
| SCHEMBL22035524 | 0.69 | — | — | |
| SCHEMBL12536559 | 0.64 | TP53 (0.34) | — | |
| SCHEMBL12536543 | 0.61 | DRD1 (0.38) | — | |
| SCHEMBL22016202 | 0.61 | KDM5B (0.45) | — | |
| SCHEMBL18997780 | 0.59 | COMT (0.40) | — | |
| SCHEMBL21652559 | 0.58 | KDM5A (0.32) | — | |
| SCHEMBL21900760 | 0.57 | COMT (0.39) | — | |
| SCHEMBL9881250 | 0.57 | — | — | |
| SCHEMBL25604490 | 0.57 | KDM5A (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |