Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13569808 | 0.91 | CACNA1I (0.44) | CACNA1IKCNH2MEN1KMT2ALMNA | |
| SCHEMBL4278224 | 0.90 | CACNA1I (0.60) | CACNA1IKCNH2MEN1KMT2ALMNA | |
| SCHEMBL26082220 | 0.80 | CACNA1I (0.74) | CACNA1IKCNH2MEN1KMT2ALMNA | |
| SCHEMBL4271317 | 0.80 | CACNA1I (0.60) | CACNA1IKCNH2MEN1KMT2ALMNA | |
| SCHEMBL18838262 | 0.78 | CACNA1I (0.72) | CACNA1IKCNH2MEN1KMT2ALMNA | |
| SCHEMBL26082223 | 0.76 | CACNA1I (0.68) | CACNA1IKCNH2MEN1KMT2ALMNA | |
| SCHEMBL13569814 | 0.76 | CACNA1I (0.57) | CACNA1IKCNH2CACNA1HCACNA1GACKR3 | |
| SCHEMBL19082642 | 0.74 | CACNA1H (0.65) | CACNA1H | |
| SCHEMBL18838427 | 0.72 | CACNA1H (0.61) | CACNA1IKCNH2MEN1KMT2ALMNA | |
| SCHEMBL26083171 | 0.72 | CACNA1I (0.67) | CACNA1IKCNH2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |