Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.69 |
| ▸ | PIKFYVE | Q9Y2I7 | 5/20 | 0.63 |
| ▸ | HCK | P08631 | 4/20 | 0.58 |
| ▸ | BTK | Q06187 | 3/20 | 0.58 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 9/20 | 0.56 |
| ▸ | LYN | P07948 | 4/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 3/20 | 0.55 |
| ▸ | STK10 | O94804 | 3/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | FYN | P06241 | 3/20 | 0.55 |
| ▸ | YES1 | P07947 | 3/20 | 0.55 |
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.55 |
| ▸ | BCR | P11274 | 3/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | PHKG2 | P15735 | 3/20 | 0.55 |
| ▸ | NQO2 | P16083 | 3/20 | 0.55 |
| ▸ | EPHA1 | P21709 | 3/20 | 0.55 |
| ▸ | FECH | P22830 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024718 | 0.87 | ABL1 (0.71) | ABL1PIKFYVEHCKBTKNR2C2 | |
| SCHEMBL22025035 | 0.86 | PIKFYVE (0.68) | ABL1PIKFYVEHCKBTKBRAF | |
| SCHEMBL22024644 | 0.85 | ABL1 (0.69) | ABL1HCKBTKNR2C2BRAF | |
| SCHEMBL22024748 | 0.83 | KIT (0.71) | ABL1BRAFLYNRETBCR | |
| SCHEMBL1653558 | 0.82 | ABL1 (0.79) | ABL1HCKBTKNR2C2BRAF | |
| SCHEMBL22024570 | 0.81 | PIKFYVE (0.77) | ABL1PIKFYVEHCKBTKBRAF | |
| SCHEMBL22025039 | 0.81 | PIKFYVE (0.60) | ABL1PIKFYVEHCKBTKBRAF | |
| SCHEMBL22024878 | 0.79 | BRAF (0.67) | BRAF | |
| SCHEMBL22024628 | 0.79 | PIKFYVE (0.60) | ABL1PIKFYVEHCKBTKBRAF | |
| SCHEMBL22024623 | 0.79 | PIKFYVE (0.62) | ABL1PIKFYVEHCKBTKBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | ABL1 1429/4885PIKFYVE 1/4885HCK 740/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | ABL1 1429/4885PIKFYVE 1/4885HCK 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.