Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.68 |
| ▸ | ABL1 | P00519 | 7/20 | 0.64 |
| ▸ | CSF1R | P07333 | 4/20 | 0.63 |
| ▸ | KIT | P10721 | 4/20 | 0.63 |
| ▸ | EGFR | P00533 | 6/20 | 0.62 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | BCR | P11274 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024747 | 0.92 | ABL1 (0.71) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22025311 | 0.89 | BRAF (0.68) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL21942987 | 0.89 | RET (0.65) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22024732 | 0.87 | BRAF (0.68) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL21942982 | 0.87 | KIT (0.62) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL21974796 | 0.87 | BRAF (0.63) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22024729 | 0.86 | BRAF (0.68) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22024712 | 0.85 | BRAF (0.68) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22024721 | 0.85 | BRAF (0.68) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22024635 | 0.83 | BRAF (0.69) | BRAFABL1CSF1RKITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | BRAF 65/4885ABL1 1429/4885CSF1R 3197/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | BRAF 65/4885ABL1 1429/4885CSF1R 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.