SCHEMBL22028065

SCHEMBL22028065

C(#Cc1ccc(C#CCOc2nsnc2C2CN3CCC2CC3)cc1)COc1nsnc1C1CN2CCC1CC2

nearest known ligand 0.89

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 13/20 0.89
CHRM1 P11229 10/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6197007 0.95 CHRM2 (0.81) CHRM2CHRM1
SCHEMBL6195475 0.95 CHRM2 (0.81) CHRM2CHRM1
SCHEMBL6198562 0.94 CHRM2 (1.00) CHRM2CHRM1
SCHEMBL21802372 0.91 CHRM2 (0.86) CHRM2CHRM1
SCHEMBL6198924 0.89 CHRM2 (0.81) CHRM2CHRM1
SCHEMBL6198955 0.89 CHRM2 (0.81) CHRM2CHRM1
SCHEMBL6197795 0.89 CHRM2 (1.00) CHRM2CHRM1
SCHEMBL6193605 0.88 CHRM2 (0.74) CHRM2CHRM1
SCHEMBL6194677 0.88 CHRM2 (0.74) CHRM2CHRM1
SCHEMBL6198189 0.87 CHRM2 (0.78) CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260147006-A1 SCREENING METHOD TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-05-28 US disclosed
US-12298319-B2 Method for measuring alpha value of muscarinic M1 receptor positive allosteric modulators TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-05-13 US disclosed
US-20230035892-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER FLAGSHIP PIONEERING, INC. 2023-02-02 US disclosed
US-11274158-B2 Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2022-03-15 US disclosed
US-20200182850-A1 SCREENING METHOD TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-06-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200182850-A1 SCREENING METHOD CHRM1, CHRM2, CHRM4 CHRM2 2/4885CHRM1 1/4885
US-12298319-B2 Method for measuring alpha value of muscarinic M1 receptor positive allosteric modulators CHRM1, CHRM2, CHRM4 CHRM2 2/4885CHRM1 1/4885
US-20260147006-A1 SCREENING METHOD CHRM1, CHRM4, CHRM5 CHRM2 4/4885CHRM1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.