Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154483 | 0.88 | PIK3CD (0.45) | RECQLTSHRCNR1MEN1KMT2A | |
| SCHEMBL20148605 | 0.86 | RECQL (0.47) | RECQLTSHRCNR1HSD11B1ALDH1A1 | |
| SCHEMBL20071310 | 0.84 | RECQL (0.44) | RECQLTSHRCNR1HSD11B1ALDH1A1 | |
| SCHEMBL20148607 | 0.81 | RECQL (0.44) | RECQLTSHRCNR1HSD11B1ALDH1A1 | |
| SCHEMBL20071302 | 0.77 | HRH3 (0.40) | RECQLTSHRCNR1GAACCR2 | |
| SCHEMBL20071305 | 0.77 | RECQL (0.52) | RECQLTSHRCNR1HSD11B1MEN1 | |
| SCHEMBL20154458 | 0.76 | RECQL (0.36) | RECQLTSHRCNR1CCR2CHRNB2 | |
| SCHEMBL26203668 | 0.76 | RECQL (0.46) | RECQLTSHRCNR1HSD11B1ALDH1A1 | |
| SCHEMBL21695514 | 0.75 | RECQL (0.48) | RECQLTSHRCNR1HSD11B1ALDH1A1 | |
| SCHEMBL22031233 | 0.75 | SMN1; SMN2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |