Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605188 | 0.75 | KDM4E (0.35) | TSHRKDM4EGAASMN1; SMN2OPRM1 | |
| SCHEMBL16487715 | 0.74 | KDM4E (0.37) | TSHRKDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL20070474 | 0.73 | KDM4E (0.34) | TSHRKDM4EGAAOPRM1OPRD1 | |
| SCHEMBL23559996 | 0.73 | TSHR (0.48) | TSHRKDM4EGAASMN1; SMN2OPRM1 | |
| SCHEMBL13082726 | 0.72 | KDM4E (0.36) | TSHRKDM4EGAASMN1; SMN2OPRM1 | |
| SCHEMBL16508773 | 0.72 | KDM4E (0.36) | TSHRKDM4EGAASMN1; SMN2OPRM1 | |
| SCHEMBL92575 | 0.72 | GAA (0.36) | TSHRKDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL6922492 | 0.70 | GAA (0.38) | TSHRKDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL6923193 | 0.70 | TSHR (0.47) | TSHRKDM4EGAASMN1; SMN2OPRM1 | |
| SCHEMBL18390356 | 0.70 | DRD4 (0.32) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |