Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22035122 | 0.96 | GRM4 (1.00) | GRM4 | |
| SCHEMBL22031339 | 0.88 | GRM4 (1.00) | GRM4 | |
| SCHEMBL22035118 | 0.88 | GRM4 (1.00) | GRM4 | |
| SCHEMBL22031377 | 0.86 | GRM4 (1.00) | GRM4 | |
| SCHEMBL22031338 | 0.86 | GRM4 (1.00) | GRM4 | |
| SCHEMBL22035121 | 0.84 | GRM4 (1.00) | GRM4 | |
| SCHEMBL22031915 | 0.84 | GRM4 (1.00) | GRM4 | |
| SCHEMBL22035417 | 0.84 | GRM4 (1.00) | GRM4 | |
| SCHEMBL24380131 | 0.84 | GRM4 (0.86) | GRM4 | |
| SCHEMBL22031355 | 0.83 | GRM4 (0.71) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319304-B2 | Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | VANDERBILT UNIVERSITY (US) | 2022-05-03 | — | — | US | disclosed |
| US-20200165232-A1 | PYRIDINE QUINOLINE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11319304-B2 | Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | GRM4, GRIK4, GRIA4 | GRM4 1/4885 |
| US-20200165232-A1 | PYRIDINE QUINOLINE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | GRM4, GRIK4, GRIA4 | GRM4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.