Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 20/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003076 | 0.79 | CHRM1 (0.52) | CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL2998936 | 0.78 | CHRM1 (0.51) | CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL12131805 | 0.78 | CHRM1 (0.52) | CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL2191074 | 0.78 | CHRM1 (0.61) | CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL1712921 | 0.78 | CHRM1 (0.43) | CHRM1CHRM5CHRM4 | |
| SCHEMBL15618889 | 0.77 | MAPT (0.52) | CHRM1CHRM5CHRM2 | |
| SCHEMBL2996155 | 0.77 | CHRM1 (0.50) | CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL15618700 | 0.77 | CHRM1 (0.53) | CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL12128829 | 0.77 | CHRM1 (0.46) | CHRM1CHRM5CHRM2CHRM4 | |
| SCHEMBL12086312 | 0.76 | CHRM1 (0.48) | CHRM1CHRM5CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3891140-A1 | BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 AND/OR M4 RECEPTOR AGONISTS | Heptares Therapeutics Limited (GB) | 2021-10-13 | — | — | EP | claimed |
| WO-2020115505-A1 | BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 AND/OR M4 RECEPTOR AGONISTS | HEPTARES THERAPEUTICS LIMITED (GB) | 2020-06-11 | — | — | WO | claimed |
| EP-3891140-A1 | BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 AND/OR M4 RECEPTOR AGONISTS | Heptares Therapeutics Limited (GB) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020115505-A1 | BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 AND/OR M4 RECEPTOR AGONISTS | HEPTARES THERAPEUTICS LIMITED (GB) | 2020-06-11 | — | — | WO | disclosed |