Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 5/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786036 | 0.84 | PDE10A (0.45) | MAPTKDM4EHTTNPC1CYP1A2 | |
| SCHEMBL12430936 | 0.83 | IGF1R (0.57) | MAPTKDM4EHTTLMNAATG4B | |
| SCHEMBL2203893 | 0.83 | MAPT (0.58) | MAPTKDM4EHTTLMNAATG4B | |
| SCHEMBL2204617 | 0.81 | KDM4E (0.56) | MAPTKDM4EHTTLMNAATG4B | |
| SCHEMBL2203882 | 0.79 | MAPT (0.56) | MAPTKDM4EHTTLMNANPC1 | |
| SCHEMBL27578751 | 0.79 | PDE10A (0.40) | MAPTKDM4EHTTLMNAATG4B | |
| SCHEMBL2202357 | 0.79 | TLR8 (0.50) | MAPTPDE10AIGF1RAURKAMEN1 | |
| SCHEMBL785990 | 0.77 | MEN1 (0.47) | MAPTKDM4ELMNANPC1RAB9A | |
| SCHEMBL16320206 | 0.75 | BRAF (0.44) | HTTMEN1KMT2ANPSR1 | |
| SCHEMBL2205969 | 0.75 | IGF1R (0.42) | MAPTKDM4EHTTLMNAATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4160395-B2 | — | — | 2008-10-01 | — | — | JP | claimed |
| CN-100406454-C | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2008-07-30 | — | — | CN | claimed |
| EP-1345927-B1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2006-05-17 | — | — | EP | claimed |
| CN-1549812-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-11-24 | — | — | CN | claimed |
| US-20040214814-A1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-28 | — | — | US | claimed |
| JP-2004518703-A | — | — | 2004-06-24 | — | — | JP | claimed |
| EP-1345927-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-09-24 | — | — | EP | claimed |
| WO-2002062789-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-08-15 | — | — | WO | claimed |
| US-7982037-B2 | (5-Methyl-2H-pyrazol-3-yl)-(2-phenylsulfanyl-quinazolin-4-yl)-amine; Anticancer agents; antidiabetic agents; Alzheimer's disease; inhibitors of Aurora-2 and GSK-3 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214814-A1 | Pyrazole compounds useful as protein kinase inhibitors | AURKC, AURKA, GSK3B | MAPT 163/4885KDM4E 1044/4885HTT 3368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.