Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 2/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881977 | 0.71 | KDM4E (0.44) | KMT2AKDM4EGPR3POLBMEN1 | |
| SCHEMBL22044210 | 0.70 | KDM4E (0.42) | KMT2AKDM4EGPR3POLBMEN1 | |
| SCHEMBL18464891 | 0.70 | KDM4E (0.42) | KMT2AKDM4EGPR3POLBMEN1 | |
| SCHEMBL18465084 | 0.66 | CYP3A4 (0.48) | KMT2ANCEH1KDM4EPOLBLMNA | |
| SCHEMBL22043762 | 0.65 | — | — | |
| SCHEMBL7315366 | 0.64 | POLB (0.50) | KMT2ANCEH1KDM4EGPR3POLB | |
| SCHEMBL30901311 | 0.63 | KDM4E (0.50) | KMT2AKDM4EGPR3POLBMEN1 | |
| SCHEMBL16552260 | 0.63 | KDM4E (0.50) | KMT2AKDM4EGPR3POLBMEN1 | |
| SCHEMBL25170252 | 0.60 | KDM4E (0.47) | KMT2AKDM4EGPR3POLBMEN1 | |
| SCHEMBL28483779 | 0.60 | KDM4E (0.47) | KMT2AKDM4EGPR3POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328859-B1 | 3-((4-ISOQUINOLIN-3-YL)METHYL)-1H-IMIDAZO[4,5-C]PYRIDIN-2(3H)-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | BOEHRINGER INGELHEIM INT (DE) | 2020-06-03 | — | — | EP | disclosed |