Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | STAT5A | P42229 | 1/20 | 0.40 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217588 | 1.00 | JAK2 (0.43) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL218751 | 0.91 | JAK2 (0.42) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL588809 | 0.87 | JAK2 (0.44) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL588501 | 0.87 | JAK2 (0.44) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL590651 | 0.87 | JAK2 (0.37) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL217329 | 0.85 | JAK2 (0.56) | JAK2JAK3NTRK1AURKAAURKB | |
| Phosphoric Acid SCHEMBL589436 | 0.82 | JAK2 (0.41) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL3665548 | 0.81 | JAK2 (0.39) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL3780040 | 0.80 | JAK2 (0.38) | JAK2JAK3NTRK1AURKAAURKB | |
| SCHEMBL589869 | 0.78 | JAK2 (0.45) | JAK2JAK3NTRK1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071480-A1 | 4-(3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER | ASTRAZENECA R&D (SE) | 2012-03-22 | — | — | US | disclosed |
| US-8088784-B2 | 4-(3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer | ASTRAZENECA AB (SE) | 2012-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071480-A1 | 4-(3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER | ABL1, FLT3, ERBB2 | JAK2 42/4885JAK3 14/4885NTRK1 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.