Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.42 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992070 | 0.79 | ERN1 (0.55) | ERN1FGFR3FGFR2FGFR1MET | |
| SCHEMBL24922493 | 0.78 | PIK3CA (0.46) | ERN1FGFR3FGFR2FGFR1FGFR4 | |
| SCHEMBL22047858 | 0.78 | MAPT (0.58) | ERN1FGFR3FGFR2FGFR1FGFR4 | |
| SCHEMBL12427762 | 0.76 | MAPT (0.59) | ERN1PIK3CG | |
| SCHEMBL18717287 | 0.75 | ERN1 (0.72) | ERN1FGFR3FGFR2FGFR1PIK3CD | |
| SCHEMBL12766775 | 0.75 | ERN1 (1.00) | ERN1 | |
| SCHEMBL5781823 | 0.75 | AURKA (0.60) | ERN1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL12427764 | 0.74 | ERN1 (0.54) | ERN1PIK3CA | |
| SCHEMBL5782678 | 0.72 | ERN1 (0.61) | ERN1 | |
| SCHEMBL9888143 | 0.71 | ALK (0.51) | ERN1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108579-A1 | AMINO-SUBSTITUTED PYRIDONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 上海海雁医药科技有限公司 | 2020-06-04 | — | — | WO | disclosed |