Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 3/20 | 0.69 |
| ▸ | GSK3B | P49841 | 3/20 | 0.69 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.69 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.69 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.69 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.69 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.69 |
| ▸ | CDC7 | O00311 | 2/20 | 0.69 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.69 |
| ▸ | NEK4 | P51957 | 2/20 | 0.69 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.69 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.69 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.69 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.69 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.69 |
| ▸ | EEF2K | O00418 | 1/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | PAK4 | O96013 | 1/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202925 | 0.92 | MARK3 (0.71) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2204047 | 0.92 | MARK3 (0.65) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2204572 | 0.91 | MARK3 (0.80) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2206392 | 0.89 | MARK3 (0.72) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2204504 | 0.88 | MARK3 (0.80) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2204365 | 0.88 | MARK3 (0.76) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2204802 | 0.87 | MARK3 (0.58) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2202644 | 0.86 | MARK3 (0.63) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2202566 | 0.86 | MARK3 (0.59) | MARK3GSK3BCAMK2BMARK2MINK1 | |
| SCHEMBL2206074 | 0.86 | MARK3 (0.72) | MARK3GSK3BCAMK2BMARK2MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8853209-B2 | 1-oxyalkyl-2-carboxy-7-nonsubstituted indole derivatives | ABBVIE INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20110263599-A1 | 7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS | ABBOTT LABORATORIES | 2011-10-27 | — | — | US | disclosed |
| US-7981888-B2 | 1-oxyalkyl-2-carboxyl-7-nonsubstituted indole derivatives | ABBOTT LABORATORIES (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090124616-A1 | 7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS | ABBOTT LABORATORIES (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124616-A1 | 7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, API5 | MARK3 2407/4885GSK3B 938/4885CAMK2B 941/4885 |
| US-20110263599-A1 | 7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, API5 | MARK3 2407/4885GSK3B 938/4885CAMK2B 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.