Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889538 | 0.97 | GRM5 (0.43) | PAK1JAK2PTK2DYRK3PRKD3 | |
| SCHEMBL22054622 | 0.87 | PAK1 (0.43) | PAK1JAK2PTK2DYRK3PRKD3 | |
| SCHEMBL22055098 | 0.85 | PAK1 (0.44) | PAK1JAK2PTK2DYRK3PRKD3 | |
| SCHEMBL24995571 | 0.83 | PAK1 (0.44) | PAK1JAK2PTK2DYRK3PRKD3 | |
| SCHEMBL22056489 | 0.82 | JAK1 (0.47) | JAK2PAK4GRM5TYK2JAK3 | |
| SCHEMBL23878888 | 0.80 | JAK3 (0.48) | PAK1JAK2PTK2DYRK3PRKD3 | |
| SCHEMBL23878886 | 0.80 | JAK3 (0.48) | PAK1JAK2PTK2DYRK3PRKD3 | |
| SCHEMBL22054647 | 0.80 | PAK1 (0.50) | PAK1JAK2PTK2DYRK3PRKD3 | |
| SCHEMBL22056479 | 0.78 | RET (0.47) | JAK2PAK4RETGRM5TYK2 | |
| SCHEMBL23889522 | 0.75 | PAK1 (0.46) | PAK1JAK2PTK2DYRK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108613-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2020-06-04 | — | — | WO | disclosed |