Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.38 |
| ▸ | CDK4 | P11802 | 6/20 | 0.35 |
| ▸ | CCND1 | P24385 | 6/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22060800 | 0.67 | MKNK1 (0.48) | — | |
| SCHEMBL5863360 | 0.65 | PARP1 (0.38) | PDE2ACDK4CCND1PARP1 | |
| SCHEMBL7603458 | 0.63 | PDE2A (0.36) | PDE2APARP1 | |
| SCHEMBL5863219 | 0.62 | PDE2A (0.39) | PDE2ACDK4CCND1PARP1 | |
| SCHEMBL3123895 | 0.62 | GRIN2D (0.41) | — | |
| SCHEMBL11396433 | 0.61 | PDE2A (0.47) | PDE2A | |
| SCHEMBL18362225 | 0.61 | PDE2A (0.39) | PDE2A | |
| SCHEMBL21957279 | 0.60 | GRIA1 (0.34) | — | |
| SCHEMBL25112475 | 0.59 | CDK4 (0.42) | PDE2ACDK4CCND1PARP1 | |
| SCHEMBL30826923 | 0.59 | KDM4E (0.55) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253397-B | MNK inhibitors | 上海迪诺医药科技有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-111253397-A | MNK inhibitors | 上海迪诺医药科技有限公司 | 2020-06-09 | — | — | CN | disclosed |
| WO-2020108619-A1 | MNK INHIBITOR | 上海迪诺医药科技有限公司 | 2020-06-04 | — | — | WO | disclosed |