Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21733377 | 1.00 | DPP4 (0.31) | DPP4P2RX3P2RX2 | |
| SCHEMBL22349100 | 1.00 | DPP4 (0.31) | DPP4P2RX3P2RX2 | |
| SCHEMBL22063552 | 1.00 | DPP4 (0.31) | DPP4P2RX3P2RX2 | |
| SCHEMBL26058976 | 1.00 | DPP4 (0.31) | DPP4P2RX3P2RX2 | |
| SCHEMBL22062724 | 1.00 | DPP4 (0.31) | DPP4P2RX3P2RX2 | |
| SCHEMBL29301892 | 0.87 | — | — | |
| SCHEMBL26711354 | 0.86 | — | — | |
| SCHEMBL26064160 | 0.83 | — | — | |
| SCHEMBL24272939 | 0.81 | DPP4 (0.31) | DPP4 | |
| SCHEMBL26004530 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760744-B2 | Fused ring compounds | GENENTECH, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| EP-4223761-A1 | QUINAZOLINE COMPOUND AND APPLICATION THEREOF | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2023-08-09 | — | — | EP | disclosed |
| US-20230002345-A1 | FUSED RING COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-01-05 | — | — | US | disclosed |
| US-11236068-B2 | Fused ring compounds | GENENTECH, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210230142-A9 | FUSED RING COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-07-29 | — | — | US | disclosed |
| US-20200181118-A1 | FUSED RING COMPOUNDS | GENENTECH INC (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230142-A9 | FUSED RING COMPOUNDS | KRAS, NRAS, HRAS | DPP4 4197/4885P2RX3 4582/4885P2RX2 4338/4885 |
| US-11760744-B2 | Fused ring compounds | KRAS, NRAS, HRAS | DPP4 4470/4885P2RX3 4714/4885P2RX2 4627/4885 |
| US-20230002345-A1 | FUSED RING COMPOUNDS | KRAS, NRAS, HRAS | DPP4 4470/4885P2RX3 4714/4885P2RX2 4627/4885 |
| US-20200181118-A1 | FUSED RING COMPOUNDS | KRAS, NRAS, HRAS | DPP4 4197/4885P2RX3 4582/4885P2RX2 4338/4885 |
| US-11236068-B2 | Fused ring compounds | KRAS, NRAS, HRAS | DPP4 4197/4885P2RX3 4582/4885P2RX2 4338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.