Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 12/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 12/20 | 0.57 |
| ▸ | ABL1 | P00519 | 8/20 | 0.56 |
| ▸ | BCR | P11274 | 6/20 | 0.56 |
| ▸ | KIT | P10721 | 4/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024549 | 0.87 | PIKFYVE (0.59) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL22024550 | 0.81 | PIKFYVE (0.65) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL13219960 | 0.80 | DDR2 (0.72) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL22024709 | 0.80 | DDR2 (0.52) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL21943727 | 0.77 | DDR2 (0.53) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL21943487 | 0.77 | DDR2 (0.54) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL22065199 | 0.77 | DDR1 (0.63) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL21943400 | 0.75 | RET (0.60) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL22024670 | 0.74 | DDR1 (0.61) | DDR2DDR1ABL1BCRKIT | |
| SCHEMBL29864626 | 0.74 | DDR2 (0.71) | DDR2DDR1ABL1BCRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |