SCHEMBL220661

SCHEMBL220661

CC(C)N1CCC(NS(=O)(=O)CCCNC(=O)c2ccc(Cl)s2)CC1

nearest known ligand 0.89

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 12/20 0.89
MAPK1 P28482 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL219798 0.94 F10 (1.00) F10MAPK1
Fumaric Acid SCHEMBL221972 0.89 F10 (0.89) F10MAPK1
SCHEMBL3873832 0.85 F10 (0.65) F10
SCHEMBL219792 0.84 F10 (0.81) F10MAPK1
SCHEMBL219921 0.83 F10 (0.80) F10
SCHEMBL222217 0.82 F10 (0.69) F10MAPK1
SCHEMBL219591 0.82 F10 (0.72) F10MAPK1
SCHEMBL222420 0.82 F10 (0.78) F10
SCHEMBL221783 0.81 F10 (0.71) F10MAPK1
SCHEMBL221386 0.80 F10 (0.74) F10MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088925-B2 low molecular weight factor Xa specific blood clotting inhibitors; less side effects; 5-Chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide; thromboembolic diseases or restenosis; antithrombotic agents SANOFI-AVENTIS (FR) 2012-01-03 US claimed
US-8088925-B2 low molecular weight factor Xa specific blood clotting inhibitors; less side effects; 5-Chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide; thromboembolic diseases or restenosis; antithrombotic agents SANOFI-AVENTIS (FR) 2012-01-03 US disclosed