Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 4/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.51 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17131157 | 0.88 | MAPK14 (0.72) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL22024818 | 0.87 | P2RX1 (0.56) | P2RX1LCKMAPK14KITSRC | |
| SCHEMBL22024983 | 0.86 | P2RX1 (0.54) | P2RX1LCKMAPK14KITSRC | |
| SCHEMBL22025352 | 0.86 | DDR2 (0.56) | P2RX1LCKMAPK14KITSRC | |
| SCHEMBL17316199 | 0.82 | P2RX1 (0.59) | P2RX1LCKMAPK14KITSRC | |
| SCHEMBL22025464 | 0.82 | P2RX1 (0.59) | P2RX1LCKMAPK14KITSRC | |
| SCHEMBL22066480 | 0.82 | MAPT (0.64) | LCKMAPK14KITSRCMAPT | |
| SCHEMBL22065195 | 0.82 | EPHB2 (0.75) | LCKMAPK14KITSRCCSF1R | |
| SCHEMBL171136 | 0.81 | P2RX1 (0.63) | P2RX1MAPTKDRTRPA1 | |
| SCHEMBL19073209 | 0.81 | BRAF (0.73) | P2RX1LCKMAPK14KITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |