Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.81 |
| ▸ | AURKA | O14965 | 6/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.57 |
| ▸ | PAK4 | O96013 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 2/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.57 |
| ▸ | PRKCG | P05129 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.57 |
| ▸ | MARK3 | P27448 | 2/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.57 |
| ▸ | BLK | P51451 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656280 | 0.89 | SYK (1.00) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL17915925 | 0.85 | SYK (0.81) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL657019 | 0.85 | SYK (0.70) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL270194 | 0.82 | SYK (0.74) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL12111055 | 0.82 | SYK (0.74) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL658155 | 0.79 | SYK (0.66) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL27612768 | 0.79 | SYK (0.70) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL27819551 | 0.79 | SYK (0.69) | SYKAURKAMAPK8CHEK1CDK2 | |
| SCHEMBL14380911 | 0.77 | IGF1R (0.74) | SYKAURKACHEK1CDK2MAPK1 | |
| SCHEMBL657020 | 0.76 | SYK (0.72) | SYKAURKAMAPK8CHEK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200181164-A1 | Thienopyranones and Furanopyranones as Checkpoint Inhibitors and Modulators of Anti-Tumor Immunity | SIGNALRX PHARMACEUTICALS, INC. (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181164-A1 | Thienopyranones and Furanopyranones as Checkpoint Inhibitors and Modulators of Anti-Tumor Immunity | CDK6, BTK, CDK1 | SYK 17/4885AURKA 168/4885MAPK8 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.