⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9139962 | 0.65 | — | — | |
| SCHEMBL18903445 | 0.64 | — | — | |
| SCHEMBL13954334 | 0.64 | — | — | |
| SCHEMBL329208 | 0.63 | — | — | |
| SCHEMBL7457067 | 0.63 | — | — | |
| SCHEMBL4281008 | 0.62 | — | — | |
| SCHEMBL19760059 | 0.61 | CRBN (0.38) | — | |
| SCHEMBL4395513 | 0.57 | — | — | |
| SCHEMBL8098039 | 0.56 | — | — | |
| SCHEMBL1411120 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886162-A | VIRAL REVERSE TRANSCRIPTASE INHIBITORS; AIDS; SIDE EFFECT REDUCTION; INCREASED ABILITY TO CROSS MEMBRANES, E.G. BLOOD BRAIN BARRIER; PHARMACOKINETICS; STORAGE FOR SUSTAINED RELEASE | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1999-03-23 | — | — | US | claimed |
| US-5177064-A | TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES | UNIVERSITY OF FLORIDA (US) | 1993-01-05 | — | — | US | claimed |
| US-4918056-A | ANTITUMOR AGENTS | HEALTH RESEARCH, INC. (ROSWELL PARK DIVISION) (US) | 1990-04-17 | — | — | US | claimed |
| CN-110709424-B | Compositions and methods for cellular immunotherapy | 科济生物医药（上海）有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-109819649-B | Solid forms of aminopurine compounds and methods of use thereof | 西格诺药品有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-108602849-B | RNA ligand-displaying exosomes for specific delivery of therapeutic agents to cells by RNA nanotechnology | 俄亥俄州国家创新基金会 | 2022-10-21 | — | — | CN | disclosed |
| CN-109069512-B | Substituted aminopurine compounds, compositions thereof, and related methods of treatment | 西格诺药品有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-114262380-A | Fusion proteins comprising modified alphavirus surface glycoproteins and tumor-associated antigens and methods thereof | 欧姆尼赛特有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-107530410-B | Fusion proteins comprising modified alphavirus surface glycoproteins and tumor-associated antigens and methods thereof | 欧姆尼赛特有限公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-113347974-A | Compositions and methods of use of 2- (4-chlorophenyl) -N- ((2- (2, 6-dioxopiperidin-3-yl) -1-oxoisoindolin-5-yl) methyl) -2, 2-difluoroacetamide | 细胞基因公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-112955179-A | Antagonistic anti-tumor necrosis factor receptor superfamily polypeptides | 综合医院公司 | 2021-06-11 | — | — | CN | disclosed |
| US-20050014752-A1 | Prodrugs of heteroaryl compounds | KORONIS PHARMACEUTICALS, INCORPORATED (US) | 2005-01-20 | — | — | US | disclosed |
| WO-2004112716-A2 | PRODRUGS OF HETEROARYL COMPOUNDS | KORONIS PHARMACEUTICALS, INCORPORATED (US) | 2004-12-29 | — | — | WO | disclosed |
| US-5886162-A | VIRAL REVERSE TRANSCRIPTASE INHIBITORS; AIDS; SIDE EFFECT REDUCTION; INCREASED ABILITY TO CROSS MEMBRANES, E.G. BLOOD BRAIN BARRIER; PHARMACOKINETICS; STORAGE FOR SUSTAINED RELEASE | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1999-03-23 | — | — | US | disclosed |
| US-4918056-A | ANTITUMOR AGENTS | HEALTH RESEARCH, INC. (ROSWELL PARK DIVISION) (US) | 1990-04-17 | — | — | US | disclosed |
| US-4321366-A | Process of preparing 2-azido-2-deoxyarabinofuranosyl halides | RESEARCH CORPORATION (US) | 1982-03-23 | — | — | US | disclosed |
| US-4230698-A | ANTITUMOR AGENTS, VIRICIDES, AND MICROBIOCIDES | RESEARCH CORPORATION (US) | 1980-10-28 | — | — | US | disclosed |
| EP-0016005-A1 | 2'-SUBSTITUTED BETA-ARABINOFURANOSYL NUCLEOSIDES AND NUCLEOTIDES, PREPARATION AND USE THEREOF. | RESEARCH CORP (US) | 1980-10-01 | — | — | EP | disclosed |
| EP-0016005-A4 | 2'-SUBSTITUTED BETA-ARABINOFURANOSYL NUCLEOSIDES AND NUCLEOTIDES, PREPARATION AND USE THEREOF. | RESEARCH CORP (US) | 1980-05-21 | — | — | EP | disclosed |
| WO-1979001068-A1 | 2'-SUBSTITUTED ARABINOFURANOSYL NUCLEOSIDES AND NUCLEOTIDES INTERMEDIATES,PREPARATION AND USE THEREOF | RESEARCH CORP (US) | 1979-12-13 | — | — | WO | disclosed |