Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15981344 | 1.00 | KDM4E (0.40) | KDM4EPOLBMAPTTDP1L3MBTL1 | |
| SCHEMBL15497903 | 0.78 | CA12 (0.46) | KDM4EPOLBMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL21755864 | 0.78 | CA12 (0.46) | KDM4EPOLBMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL24611844 | 0.78 | POLB (0.36) | KDM4EPOLBMAPTTDP1L3MBTL1 | |
| SCHEMBL8409901 | 0.78 | MAPT (0.36) | KDM4EPOLBMAPTTDP1L3MBTL1 | |
| SCHEMBL19598101 | 0.78 | TSHR (0.41) | KDM4EMAPTALDH1A1NPSR1CYP2C9 | |
| SCHEMBL12740474 | 0.77 | POLB (0.43) | KDM4EPOLBMAPTTDP1L3MBTL1 | |
| SCHEMBL29566126 | 0.77 | MAPT (0.46) | KDM4EPOLBMAPTTDP1L3MBTL1 | |
| SCHEMBL5496315 | 0.77 | MAPT (0.46) | KDM4EPOLBMAPTTDP1L3MBTL1 | |
| SCHEMBL5496317 | 0.77 | MAPT (0.46) | KDM4EPOLBMAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020114482-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | 中国科学院上海药物研究所 | 2020-06-11 | — | — | WO | disclosed |