Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 11/20 | 0.64 |
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22083658 | 0.94 | USP30 (0.56) | USP30PARP1POLBHDAC4LMNA | |
| SCHEMBL22082709 | 0.84 | USP30 (0.57) | USP30PARP1HDAC4HDAC6GABRA5 | |
| SCHEMBL22131008 | 0.83 | USP30 (0.77) | USP30PARP1HDAC4HDAC6MEN1 | |
| SCHEMBL18116012 | 0.82 | USP30 (0.74) | USP30HDAC4HDAC6MEN1KMT2A | |
| SCHEMBL994594 | 0.81 | USP30 (0.71) | USP30PARP1BTKHDAC4HDAC6 | |
| SCHEMBL4921150 | 0.81 | USP30 (0.71) | USP30PARP1BTKHDAC4HDAC6 | |
| SCHEMBL4924196 | 0.81 | USP30 (0.71) | USP30PARP1BTKHDAC4HDAC6 | |
| SCHEMBL22083473 | 0.81 | HDAC1 (0.46) | USP30HDAC4HDAC6GABRA5 | |
| SCHEMBL22083472 | 0.80 | USP30 (0.54) | USP30PARP1POLBLMNAMEN1 | |
| SCHEMBL23019697 | 0.78 | USP30 (1.00) | USP30PARP1POLBHDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117075-A1 | ARYLSULFONAMIDES OF 2-ARYLPYRROLE-3-CARBOXAMIDES FOR THE TREATMENT OF CNS DISORDERS | JAGIELLONIAN UNIVERSITY (PL) | 2020-06-11 | — | — | WO | disclosed |