Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19853349 | 1.00 | GRIN2B (0.70) | GRIN2BGRIN2C | |
| SCHEMBL24634182 | 1.00 | GRIN2B (0.70) | GRIN2BGRIN2C | |
| SCHEMBL24634183 | 0.93 | GRIN2B (0.62) | GRIN2BGRIN2C | |
| SCHEMBL22087526 | 0.83 | GRIN2B (0.50) | GRIN2BGRIN2C | |
| SCHEMBL19853333 | 0.83 | GRIN2B (0.50) | GRIN2BGRIN2C | |
| SCHEMBL22086449 | 0.82 | GRIN2B (0.49) | GRIN2BGRIN2C | |
| SCHEMBL19853350 | 0.82 | GRIN2B (0.49) | GRIN2BGRIN2C | |
| Zelquistinel SCHEMBL15936939 | 0.82 | GRIN2B (1.00) | GRIN2BGRIN2C | |
| Zelquistinel SCHEMBL24636775 | 0.82 | GRIN2B (1.00) | GRIN2BGRIN2C | |
| Zelquistinel SCHEMBL19629083 | 0.82 | GRIN2B (1.00) | GRIN2BGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028095-B2 | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof | APTINYX INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-20200181159-A1 | SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181159-A1 | SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | GRIN1, GRIN2A, GRIN2C | GRIN2B 4/4885GRIN2C 3/4885 |
| US-11028095-B2 | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof | GRIN1, GRIN2A, GRIN2C | GRIN2B 4/4885GRIN2C 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.