Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756370 | 0.80 | CYP2C19 (0.50) | CYP2C19RAB9ACTSCHPGDALDH1A1 | |
| SCHEMBL755382 | 0.80 | CYP2C19 (0.50) | CYP2C19RAB9ACTSCHPGDALDH1A1 | |
| SCHEMBL11982189 | 0.80 | CYP2C19 (0.50) | CYP2C19RAB9ACTSCHPGDALDH1A1 | |
| SCHEMBL2628076 | 0.77 | CYP2C19 (0.48) | CYP2C19RAB9ACTSCHPGDALDH1A1 | |
| SCHEMBL5724646 | 0.77 | CYP2C19 (0.62) | CYP2C19RAB9ACTSCHPGDALDH1A1 | |
| SCHEMBL2027703 | 0.76 | CYP2C19 (0.61) | CYP2C19RAB9ACTSCHPGDPOLB | |
| SCHEMBL29065802 | 0.76 | CYP2C19 (0.61) | CYP2C19RAB9ACTSCHPGDALDH1A1 | |
| SCHEMBL2027702 | 0.76 | CYP2C19 (0.61) | CYP2C19RAB9ACTSCHPGDPOLB | |
| SCHEMBL28814778 | 0.76 | CYP2C19 (0.61) | CYP2C19RAB9ACTSCHPGDALDH1A1 | |
| SCHEMBL288287 | 0.76 | CYP2C19 (0.61) | CYP2C19RAB9ACTSCHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220226434-A1 | METHODS OF TREATING HYPERLIPIDEMIA CONDITIONS WITH NETRIN-1 COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-07-21 | — | — | US | disclosed |
| US-20210371463-A1 | Modified Netrin-1 Peptides and Compositions for Cardioprotection | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-12-02 | — | — | US | disclosed |
| US-20210332083-A1 | Netrin-1 Compounds and Compositions Thereof for Treating Pulmonary Hypertension | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-10-28 | — | — | US | disclosed |
| EP-3893895-A1 | NETRIN-1 COMPOUNDS AND COMPOSITIONS THEREOF FOR TREATING PULMONARY HYPERTENSION | The Regents of University of California (US) | 2021-10-20 | — | — | EP | disclosed |
| EP-3893894-A1 | MODIFIED NETRIN-1 PEPTIDES AND COMPOSITIONS FOR CARDIOPROTECTION | The Regents of University of California (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123578-A1 | NETRIN-1 COMPOUNDS AND COMPOSITIONS THEREOF FOR TREATING PULMONARY HYPERTENSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-18 | — | — | WO | disclosed |
| WO-2020123576-A1 | MODIFIED NETRIN-1 PEPTIDES AND COMPOSITIONS FOR CARDIOPROTECTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-18 | — | — | WO | disclosed |