Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1107023 | 0.82 | CA12 (0.54) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL21795443 | 0.79 | CA12 (0.46) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL21795553 | 0.78 | CA12 (0.50) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL25806630 | 0.77 | CA1 (0.50) | TSHRALDH1A1POLBCYP2C9LMNA | |
| SCHEMBL3778721 | 0.76 | CA12 (0.43) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL15893902 | 0.75 | SMN1; SMN2 (0.50) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL21795554 | 0.74 | CA12 (0.45) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL22563805 | 0.73 | CA12 (0.54) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL9609226 | 0.73 | CA12 (0.54) | CA12CA7CA14SMN1; SMN2TSHR | |
| SCHEMBL10263887 | 0.72 | CA12 (0.48) | CA12CA7CA14SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894396-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123395-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-06-18 | — | — | WO | disclosed |