SCHEMBL22096046

SCHEMBL22096046

COC(O)c1nonc1NCn1nnnc1-c1cccc(OC(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
STAT5B P51692 1/20 0.42
PIM1 P11309 13/20 0.37
PIM2 Q9P1W9 5/20 0.36
PIM3 Q86V86 2/20 0.36
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22096042 0.84 STAT5B (0.54) STAT5BPIM1PIM2PIM3POLB
SCHEMBL22096023 0.81 STAT5B (0.65) STAT5BPIM1PIM2PIM3POLB
SCHEMBL22096040 0.73 STAT5B (0.55) STAT5BPOLB
SCHEMBL22096041 0.70 STAT5B (0.56) STAT5B
SCHEMBL22096017 0.69 STAT5B (0.65) STAT5BPOLB
SCHEMBL22096043 0.67 STAT5B (0.68) STAT5BPOLB
SCHEMBL22096019 0.67 STAT5B (0.62) STAT5B
SCHEMBL22096045 0.67 STAT5B (0.61) STAT5B
SCHEMBL22096024 0.66 STAT5B (0.79) STAT5BPOLB
SCHEMBL5905971 0.64 POLB (0.52) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10683286-B2 Furazan-3-carboxylic acid derivatives and use thereof in treatment of cancer FREIE UNIVERSITAET BERLIN (DE) 2020-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10683286-B2 Furazan-3-carboxylic acid derivatives and use thereof in treatment of cancer FLT3, MCL1, MYD88 STAT5B 59/4885PIM1 1492/4885PIM2 1784/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.