Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 15/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.36 |
| ▸ | CDK9 | P50750 | 9/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.35 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29585797 | 0.77 | NTRK1 (0.39) | FLT3EPHB3 | |
| SCHEMBL22097340 | 0.76 | EPHB3 (0.39) | FLT3EPHB3 | |
| SCHEMBL19560147 | 0.76 | SMPD3 (0.58) | — | |
| SCHEMBL852388 | 0.76 | FLT3 (0.50) | FLT3PIK3CACCNT1CDK9CDK7 | |
| SCHEMBL22097391 | 0.75 | PIM1 (0.34) | FLT3PIK3CACCNT1CDK9 | |
| SCHEMBL22858069 | 0.70 | — | — | |
| SCHEMBL22857969 | 0.70 | LRRK2 (0.32) | — | |
| SCHEMBL25157822 | 0.69 | PIK3CA (0.43) | FLT3PIK3CACCNT1CDK9CDK7 | |
| SCHEMBL22089810 | 0.69 | SMPD3 (0.57) | FLT3PIK3CA | |
| SCHEMBL3037759 | 0.69 | FLT3 (0.39) | FLT3PIK3CACCNT1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020119205-A1 | RADIOACTIVE FLUORINE-LABELED LAROTRECTINIB COMPOUND AND PREPARATION METHOD THEREFOR | 上海健康医学院 | 2020-06-18 | — | — | WO | disclosed |
| WO-2020119206-A1 | RADIOACTIVE IODINE-LABELLED LAROTRECTINIB COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海健康医学院 | 2020-06-18 | — | — | WO | disclosed |