Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 5/20 | 0.60 |
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211255 | 0.91 | FGFR2 (0.60) | FGFR2KDRPDGFRAKITAXL | |
| SCHEMBL3696493 | 0.90 | FGFR2 (0.46) | FGFR2KDRPDGFRA | |
| SCHEMBL2207779 | 0.88 | FGFR2 (0.56) | FGFR2KDRPDGFRAKITAXL | |
| SCHEMBL2209810 | 0.88 | FGFR2 (0.62) | FGFR2KDRPDGFRAKITAXL | |
| SCHEMBL2970704 | 0.85 | MAPT (0.41) | FGFR2KDR | |
| SCHEMBL2207029 | 0.85 | FGFR2 (0.72) | FGFR2KDRPDGFRAKITAXL | |
| SCHEMBL2208767 | 0.84 | FGFR2 (0.51) | FGFR2KDRPDGFRAKITAXL | |
| SCHEMBL3704889 | 0.83 | FGFR2 (0.47) | FGFR2KDRPDGFRA | |
| SCHEMBL2210388 | 0.83 | FGFR2 (0.63) | FGFR2KDRPDGFRAKITAXL | |
| SCHEMBL15663316 | 0.82 | FGFR2 (0.48) | FGFR2KDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981891-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2011-07-19 | — | — | US | claimed |
| US-20100280008-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2010-11-04 | — | — | US | claimed |
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280008-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AURKC, AURKA, CDK1 | FGFR2 334/4885KDR 644/4885PDGFRA 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.