Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089701 | 1.00 | CDK4 (0.54) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL28600652 | 1.00 | CDK4 (0.54) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL29942188 | 1.00 | CDK4 (0.54) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL29942180 | 1.00 | CDK4 (0.54) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL22089803 | 0.92 | JAK3 (0.51) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL22089913 | 0.92 | JAK3 (0.51) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL29941674 | 0.92 | JAK3 (0.51) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL29941738 | 0.92 | JAK3 (0.51) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL27215624 | 0.92 | JAK3 (0.51) | CDK4CDK6CDK2CCNA2JAK2 | |
| SCHEMBL22114534 | 0.91 | CDK4 (0.57) | CDK4CDK6CDK2CCNA2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030870-B2 | Benzamides of pyrazolylamino-pyrimidinyl derivatives, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-09 | — | — | US | disclosed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| US-20240025882-A1 | BENZAMIDES OF PYRAZOLYLAMINO- PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| US-20230002362-A1 | BENZAMIDES OF PYRAZOLYLAMINO- PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2023-01-05 | — | — | US | disclosed |
| WO-2020119819-A1 | BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2020-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030870-B2 | Benzamides of pyrazolylamino-pyrimidinyl derivatives, and compositions and methods thereof | JAK2, JAK1, JAK3 | CDK4 80/4885CDK6 89/4885CDK2 49/4885 |
| US-20230002362-A1 | BENZAMIDES OF PYRAZOLYLAMINO- PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | JAK1, JAK3, JAK2 | CDK4 92/4885CDK6 121/4885CDK2 115/4885 |
| US-20240025882-A1 | BENZAMIDES OF PYRAZOLYLAMINO- PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | JAK2, JAK1, JAK3 | CDK4 80/4885CDK6 89/4885CDK2 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.