Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | TYK2 | P29597 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | STAT3 | P40763 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CDK9 | P50750 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27452000 | 0.85 | JAK1 (0.47) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL27450355 | 0.84 | KDR (0.40) | JAK2JAK1TYK2JAK3CDK1 | |
| SCHEMBL24853255 | 0.83 | MAPK1 (0.49) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL28612291 | 0.83 | MAPK1 (0.49) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL29942003 | 0.83 | MAPK1 (0.49) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL24852488 | 0.82 | CCNT1 (0.43) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL27449865 | 0.80 | JAK2 (0.51) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL24853257 | 0.79 | MAPK1 (0.46) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL24853456 | 0.78 | MAP3K14 (0.46) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL22544660 | 0.77 | CDK19 (0.57) | JAK2JAK1TYK2JAK3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020119819-A1 | BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2020-06-18 | — | — | WO | disclosed |