Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900037 | 1.00 | NQO2 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| SCHEMBL29561955 | 1.00 | NQO2 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| SCHEMBL3143084 | 1.00 | NQO2 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| SCHEMBL224105 | 1.00 | NQO2 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| SCHEMBL28004385 | 1.00 | NQO2 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL385259 | 0.98 | NQO2 (0.42) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL30626131 | 0.98 | NQO2 (0.42) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL29693806 | 0.98 | NQO2 (0.42) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL547432 | 0.98 | NQO2 (0.42) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL29693778 | 0.98 | NQO2 (0.42) | NQO2MTNR1AMTNR1BCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 208 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809554-B2 | Process for preparing ivabradine | OLON S.P.A. (IT) | 2017-11-07 | — | — | US | claimed |
| CN-104788377-B | Preparation method of ivabradine and pharmaceutical salt thereof | 浙江美诺华药物化学有限公司 | 2017-04-19 | — | — | CN | claimed |
| CN-104557573-A | Preparation method of (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride | SHANGHAI TIANCI BIOLOG VALLEY BIOLOG ENGINEERING CO LTD | 2015-04-29 | — | — | CN | claimed |
| EP-2213651-B1 | RESOLUTION OF 4,5-DIMETHOXY-1-(METHYLAMINOMETHYL)-BENZOCYCLOBUTANE | JIANGSU HENGRUI MEDICINE CO (CN) | 2012-12-19 | — | — | EP | claimed |
| US-8198485-B2 | Resolution of 4,5-dimethoxy-1-(methylaminomenthyl)-benzocyclobutane | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2012-06-12 | — | — | US | claimed |
| EP-2097383-B1 | Process for preparation of ivabradine hydrochloride | CADILA HEALTHCARE LTD (IN) | 2012-02-08 | — | — | EP | claimed |
| EP-2213651-A1 | RESOLUTION OF 4,5-DIMETHOXY-1-(METHYLAMINOMETHYL)-BENZOCYCLOBUTANE | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-08-04 | — | — | EP | claimed |
| EP-2097383-A2 | PROCESS FOR PREPARATION OF IVABRADINE HYDROCHLORIDE | Cadila Healthcare Limited (IN) | 2009-09-09 | — | — | EP | claimed |
| CN-101284813-A | Preparation method of ivabradine | SHANGHAI UTOPHARM CO LTD (CN) | 2008-10-15 | — | — | CN | claimed |
| WO-2008065681-A2 | PROCESS FOR PREPARATION OF IVABRADINE HYDROCHLORIDE | CADILA HEALTHCARE LIMITED (IN) | 2008-06-05 | — | — | WO | claimed |
| CN-114324714-B | Method for detecting (1S) -4, 5-dimethoxy-1- [ (methylamino) methyl ] benzocyclobutane hydrochloride | 海南鑫开源医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-114324715-B | Detection method of related substances in 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-112946143-B | Analysis and detection method of 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-111220727-B | Method for detecting enantiomer in ivabradine hydrochloride intermediate and application | 北京鑫开元医药科技有限公司海南分公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-114324714-A | Method for detecting (1S) -4, 5-dimethoxy-1- [ (methylamino) methyl ] benzocyclobutane hydrochloride | 海南鑫开源医药科技有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-6982350-B2 | Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2006-01-03 | — | — | US | disclosed |
| US-6982350-B2 | Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2006-01-03 | — | — | US | disclosed |
| US-20050261376-A1 | PROCESS FOR THE SYNTHESIS OF (IS)-4,5-DIMETHOXY-1-(METHYLAMINOMETHYL)-BENZOCYCLOBUTANE AND ADDITION SALTS THEREOF, AND TO THE APPLICATION THEREOF IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID | LES LABORATOIRES SERVIER (FR) | 2005-11-24 | — | — | US | disclosed |
| EP-1598333-A1 | Process for the preparation of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, acid addition salts thereof and its use for the synthesis of ivabradine and for its pharmaceutically acceptable acid addition salts | Les Laboratoires Servier (FR) | 2005-11-23 | — | — | EP | disclosed |
| EP-1598333-A1 | Process for the preparation of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, acid addition salts thereof and its use for the synthesis of ivabradine and for its pharmaceutically acceptable acid addition salts | Les Laboratoires Servier (FR) | 2005-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261376-A1 | PROCESS FOR THE SYNTHESIS OF (IS)-4,5-DIMETHOXY-1-(METHYLAMINOMETHYL)-BENZOCYCLOBUTANE AND ADDITION SALTS THEREOF, AND TO THE APPLICATION THEREOF IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID | CYP4B1, CYP4F2, CYP2S1 | NQO2 1117/4885MTNR1A 2450/4885MTNR1B 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.