SCHEMBL22100968

C/C(=C\[C@H](C(C)C)N(C)C(=O)[C@@H](NC1OC1[C@H]1CCCCN1C(C)C)C(C)(C)C)C(=O)N[C@H](CCC(=O)NCCN1C(=O)C=CC1=O)C(=O)O

nearest known ligand 0.33

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	TUBB1	Q9H4B7	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22309342	0.87	TUBB1 (0.36)	TUBB1
SCHEMBL20732462	0.87	TUBB1 (0.36)	TUBB1
SCHEMBL24409968	0.80	TUBB1 (0.58)	TUBB1
SCHEMBL20732361	0.80	TUBB1 (0.58)	TUBB1
SCHEMBL24410271	0.79	TUBB1 (0.33)	TUBB1
SCHEMBL24115035	0.76	—	—
SCHEMBL24409971	0.75	TUBB1 (0.47)	TUBB1
SCHEMBL24410046	0.75	TUBB1 (0.40)	TUBB1
SCHEMBL24410030	0.75	TUBB1 (0.50)	TUBB1
SCHEMBL24410045	0.75	TUBB1 (0.50)	TUBB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3666787-A1	ANTIBODY-DRUG CONJUGATES INCLUDING HEMIASTERLIN DERIVATIVE	Sumitomo Dainippon Pharma Co., Ltd. (JP)	2020-06-17	—	—	EP	disclosed