SCHEMBL22101072

C/C(=C\[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](C)C(C)(C)c1cccc(-c2ccccc2)c1)C(C)(C)C)C(=O)ON1C(=O)CCC1=O

nearest known ligand 0.46

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	TUBB1	Q9H4B7	2/20	0.46

▸	MMP2	P08253	1/20	0.30

▸	MMP3	P08254	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20732284	0.93	TUBB1 (0.56)	TUBB1MMP2MMP3
SCHEMBL22308496	0.93	TUBB1 (0.56)	TUBB1MMP2MMP3
SCHEMBL24360595	0.85	TUBB1 (0.64)	TUBB1
SCHEMBL22309210	0.84	TUBB1 (0.57)	TUBB1MMP3
SCHEMBL20732280	0.84	TUBB1 (0.57)	TUBB1MMP3
SCHEMBL22308509	0.83	TUBB1 (0.56)	TUBB1
SCHEMBL20732281	0.83	TUBB1 (0.56)	TUBB1
SCHEMBL22309069	0.83	TUBB1 (0.56)	TUBB1
SCHEMBL20732282	0.83	TUBB1 (0.56)	TUBB1
SCHEMBL22069839	0.82	TUBB1 (0.48)	TUBB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3666787-A1	ANTIBODY-DRUG CONJUGATES INCLUDING HEMIASTERLIN DERIVATIVE	Sumitomo Dainippon Pharma Co., Ltd. (JP)	2020-06-17	—	—	EP	disclosed