Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210509 | 1.00 | KMT2A (0.53) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2213353 | 0.90 | MAPT (0.49) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2212729 | 0.90 | MAPT (0.49) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2209649 | 0.88 | TSHR (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2210376 | 0.88 | TSHR (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2213268 | 0.87 | PLK1 (0.48) | KMT2AMEN1ALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL2213252 | 0.87 | PLK1 (0.48) | KMT2AMEN1ALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL2212730 | 0.87 | MEN1 (0.56) | KMT2AMEN1ALDH1A1KDM4EHTT | |
| SCHEMBL2212726 | 0.87 | MEN1 (0.56) | KMT2AMEN1ALDH1A1KDM4EHTT | |
| SCHEMBL2210291 | 0.86 | PLK1 (0.49) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534284-B1 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2011-07-27 | — | — | EP | claimed |
| EP-1534284-B1 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2011-07-27 | — | — | EP | disclosed |