Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 19/20 | 0.81 |
| ▸ | MAPK9 | P45984 | 19/20 | 0.81 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.81 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.68 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CCNH | P51946 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22106110 | 0.92 | MAPK8 (0.88) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22106042 | 0.92 | MAPK8 (0.88) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095513 | 0.89 | MAPK8 (1.00) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095486 | 0.89 | MAPK8 (1.00) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095484 | 0.89 | MAPK8 (1.00) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095697 | 0.87 | MAPK8 (0.76) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095687 | 0.86 | MAPK8 (1.00) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095700 | 0.86 | MAPK8 (1.00) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095685 | 0.86 | MAPK8 (1.00) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 | |
| SCHEMBL22095528 | 0.86 | MAPK8 (1.00) | MAPK8MAPK9PIKFYVEMAPK10MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123925-A1 | PYRAZOLOPYRIDINE INHIBITORS OF C-JUN-N-TERMINAL KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-06-18 | — | — | WO | disclosed |