Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22111312 | 0.86 | GLA (0.38) | GLAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL22100971 | 0.85 | KDM4E (0.42) | GLAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL23394108 | 0.84 | MEN1 (0.35) | ALDH1A1SMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL22111268 | 0.83 | GLA (0.42) | GLAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8876247 | 0.83 | GLA (0.48) | GLAALDH1A1SMN1; SMN2KDM4ENR4A2 | |
| SCHEMBL14567800 | 0.81 | TUBB1 (0.42) | GLAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL57852 | 0.81 | TUBB1 (0.42) | GLAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL22070143 | 0.81 | GLA (0.52) | GLAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL22070144 | 0.81 | GLA (0.52) | GLAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL26607779 | 0.79 | TUBB1 (0.50) | GLAALDH1A1SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666788-A1 | HEMIASTERLIN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES INCLUDING SAME | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2020-06-17 | — | — | EP | disclosed |