Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | KCNK5 | O95279 | 1/20 | 0.57 |
| ▸ | KCNK17 | Q96T54 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2204592 | 0.93 | KCNA5 (0.67) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| Trifluoroacetic Acid SCHEMBL5697891 | 0.83 | KCNA5 (0.51) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL12434044 | 0.79 | KCNA5 (0.74) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL12434391 | 0.78 | KCNA5 (0.83) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL2208881 | 0.78 | KCNA5 (0.70) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL2208671 | 0.77 | KCNA5 (1.00) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL12434042 | 0.77 | KCNA5 (0.71) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| SCHEMBL12434022 | 0.76 | KCNA5 (0.70) | KCNA5KCNK3KCNK5KCNK17KCNK9 | |
| Trifluoroacetic Acid SCHEMBL4243585 | 0.76 | IDO1 (0.44) | GSK3BMAOBALDH1A1 | |
| SCHEMBL12434333 | 0.76 | KCNA5 (0.69) | KCNA5KCNK3KCNK5KCNK17KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7982045-B2 | 2′-substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-07-19 | — | — | US | disclosed |