Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12766948 | 0.88 | NAMPT (0.40) | TP53NAMPTRXFP1F3SMN1; SMN2 | |
| SCHEMBL1499555 | 0.84 | NAMPT (0.45) | NAMPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL1499557 | 0.84 | NAMPT (0.45) | NAMPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL1499537 | 0.81 | NAMPT (0.40) | TP53NAMPTRXFP1F3SMN1; SMN2 | |
| SCHEMBL1499538 | 0.81 | NAMPT (0.40) | TP53NAMPTRXFP1F3SMN1; SMN2 | |
| SCHEMBL1499437 | 0.81 | SMN1; SMN2 (0.48) | NAMPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL1499539 | 0.77 | NAMPT (0.47) | NAMPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL1499624 | 0.77 | NPC1 (0.43) | TP53NAMPTRXFP1F3SMN1; SMN2 | |
| SCHEMBL1499621 | 0.77 | NPC1 (0.43) | TP53NAMPTRXFP1F3SMN1; SMN2 | |
| SCHEMBL1499597 | 0.77 | TP53 (0.47) | TP53NAMPTRXFP1F3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235000-B1 | CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES | CENTRE NAT RECH SCIENT (FR) | 2020-06-17 | — | — | EP | disclosed |