Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.76 |
| ▸ | PIM1 | P11309 | 2/20 | 0.76 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.76 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.76 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211567 | 1.00 | PIM2 (0.76) | PIM2PIM1CSNK2A2CSNK2A1CHEK1 | |
| SCHEMBL12512814 | 0.89 | PIM2 (0.81) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL2214184 | 0.86 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL2212990 | 0.86 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL2213768 | 0.86 | PIM2 (0.81) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL2213763 | 0.86 | PIM2 (0.81) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL2211569 | 0.86 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1CHEK1 | |
| SCHEMBL2211571 | 0.86 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1CHEK1 | |
| SCHEMBL2213503 | 0.85 | PIM2 (0.75) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL2213509 | 0.85 | PIM2 (0.75) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318723-B2 | Pyrazine compounds, their use and methods of preparation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-27 | — | — | US | claimed |
| EP-2061762-B1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INT (DE) | 2011-07-27 | — | — | EP | claimed |
| US-20100210627-A1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-19 | — | — | US | claimed |
| US-8318723-B2 | Pyrazine compounds, their use and methods of preparation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-27 | — | — | US | disclosed |
| US-8318723-B2 | Pyrazine compounds, their use and methods of preparation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-27 | — | — | US | disclosed |
| US-8318723-B2 | Pyrazine compounds, their use and methods of preparation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-27 | — | — | US | disclosed |
| EP-2061762-B1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INT (DE) | 2011-07-27 | — | — | EP | disclosed |
| EP-2061762-B1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INT (DE) | 2011-07-27 | — | — | EP | disclosed |
| US-20100210627-A1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-19 | — | — | US | disclosed |
| US-20100210627-A1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-19 | — | — | US | disclosed |
| US-20100210627-A1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-19 | — | — | US | disclosed |
| WO-2008022164-A2 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210627-A1 | PYRAZINE COMPOUNDS, THEIR USE AND METHODS OF PREPARATION | CDK2, PIM1, CCNK | PIM2 16/4885PIM1 2/4885CSNK2A2 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.