Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22116308 | 1.00 | PTGDR2 (0.39) | PTGDR2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22116403 | 0.95 | PTGDR2 (0.42) | PTGDR2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22116341 | 0.93 | GCK (0.37) | PTGDR2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22116357 | 0.90 | PTGDR2 (0.49) | PTGDR2SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL22116359 | 0.89 | PTGDR2 (0.38) | PTGDR2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22116360 | 0.89 | PTGDR2 (0.38) | PTGDR2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22116418 | 0.89 | PTGDR2 (0.38) | PTGDR2DRD4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24234234 | 0.88 | PTGDR2 (0.51) | PTGDR2SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL22116373 | 0.88 | PTGDR2 (0.51) | PTGDR2SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL22116338 | 0.86 | PTGDR2 (0.38) | PTGDR2DRD4SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897832-A1 | N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE | Novartis AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020128768-A1 | N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE | NOVARTIS AG (CH) | 2020-06-25 | — | — | WO | disclosed |