Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 19/20 | 0.54 |
| ▸ | KDR | P35968 | 19/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 17/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 17/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 15/20 | 0.49 |
| ▸ | FLT3 | P36888 | 8/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31655651 | 1.00 | FGFR3 (0.54) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL22149353 | 0.93 | FGFR3 (0.53) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL31655652 | 0.93 | FGFR3 (0.53) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL31655615 | 0.93 | FGFR3 (0.53) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL22149691 | 0.93 | FGFR3 (0.53) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL31655621 | 0.92 | FGFR3 (0.51) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL22149195 | 0.92 | FGFR3 (0.51) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL22149350 | 0.89 | FGFR3 (0.56) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL31655633 | 0.89 | FGFR3 (0.56) | FGFR3KDRFGFR4FGFR1FGFR2 | |
| SCHEMBL22122045 | 0.89 | FGFR3 (0.55) | FGFR3KDRFGFR4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898615-A1 | 7-((3,5-DIMETHOXYPHENYL)AMINO)QUINOXALINE DERIVATIVES AS FGFR INHIBITORS FOR TREATING CANCER | Array Biopharma, Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020131674-A1 | 7-((3,5-DIMETHOXYPHENYL)AMINO)QUINOXALINE DERIVATIVES AS FGFR INHIBITORS FOR TREATING CANCER | ARRAY BIOPHARMA INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020131674-A1 | 7-((3,5-DIMETHOXYPHENYL)AMINO)QUINOXALINE DERIVATIVES AS FGFR INHIBITORS FOR TREATING CANCER | ARRAY BIOPHARMA INC. (US) | 2020-06-25 | — | — | WO | disclosed |