Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 5/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 4/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30171532 | 1.00 | MAPKAPK5 (0.34) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL22123785 | 0.96 | MAPKAPK5 (0.35) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL22123001 | 0.94 | MAPKAPK5 (0.33) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL22123048 | 0.93 | HTR2A (0.40) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL30171576 | 0.93 | MAPKAPK5 (0.33) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL22124583 | 0.93 | MAPKAPK5 (0.33) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL22122823 | 0.93 | MAPKAPK5 (0.33) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL22122906 | 0.93 | MAPKAPK5 (0.34) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL22123702 | 0.93 | TTK (0.34) | MAPKAPK5PTK6TTKCDK2SYK | |
| SCHEMBL30183552 | 0.93 | TTK (0.38) | MAPKAPK5PTK6TTKCDK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113195497-A | Novel imidazopyrazine derivatives | 豪夫迈·罗氏有限公司 | 2021-07-30 | — | — | CN | claimed |
| EP-3898631-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| CN-113195497-A | Novel imidazopyrazine derivatives | 豪夫迈·罗氏有限公司 | 2021-07-30 | — | — | CN | disclosed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |