Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | BCL6 | P41182 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123658 | 1.00 | PTK6 (0.42) | PTK6LRRK2BCL6SYKSTK17B | |
| SCHEMBL22123365 | 1.00 | PTK6 (0.42) | PTK6LRRK2BCL6SYKSTK17B | |
| Hydrochloric Acid SCHEMBL30171588 | 0.99 | PTK6 (0.41) | PTK6LRRK2BCL6SYKSTK17B | |
| Hydrochloric Acid SCHEMBL30171873 | 0.99 | PTK6 (0.41) | PTK6LRRK2BCL6SYKSTK17B | |
| Hydrochloric Acid SCHEMBL30171924 | 0.99 | PTK6 (0.41) | PTK6LRRK2BCL6SYKSTK17B | |
| SCHEMBL22124504 | 0.99 | PTK6 (0.42) | PTK6LRRK2BCL6SYKSTK17B | |
| Hydrochloric Acid SCHEMBL30171699 | 0.99 | PTK6 (0.42) | PTK6LRRK2BCL6SYKSTK17B | |
| SCHEMBL22123010 | 0.92 | TTK (0.39) | PTK6LRRK2SYKTTKMAPKAPK5 | |
| SCHEMBL22123018 | 0.92 | TTK (0.39) | PTK6LRRK2SYKTTKMAPKAPK5 | |
| SCHEMBL22123423 | 0.92 | TTK (0.39) | PTK6LRRK2SYKTTKMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-12 | — | — | US | disclosed |
| EP-3898631-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, MYD88, IL1R1 | PTK6 2211/4885LRRK2 2383/4885BCL6 4009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.