Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 8/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | TTK | P33981 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.34 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22124102 | 1.00 | PTK6 (0.41) | PTK6AURKBLCKTTKALDH1A1 | |
| SCHEMBL22154600 | 1.00 | PTK6 (0.41) | PTK6AURKBLCKTTKALDH1A1 | |
| SCHEMBL30177661 | 1.00 | PTK6 (0.41) | PTK6AURKBLCKTTKALDH1A1 | |
| SCHEMBL22124904 | 0.94 | PTK6 (0.40) | PTK6AURKBLCKTTKALDH1A1 | |
| SCHEMBL30177735 | 0.94 | PTK6 (0.40) | PTK6AURKBLCKTTKALDH1A1 | |
| SCHEMBL30177777 | 0.91 | PTK6 (0.41) | PTK6AURKBLCKTTKERBB2 | |
| SCHEMBL22124540 | 0.91 | PTK6 (0.41) | PTK6AURKBLCKTTKERBB2 | |
| SCHEMBL22139069 | 0.91 | PTK6 (0.44) | PTK6AURKBLCKTTKALDH1A1 | |
| SCHEMBL22139059 | 0.91 | PTK6 (0.44) | PTK6AURKBLCKTTKALDH1A1 | |
| SCHEMBL30171977 | 0.91 | PTK6 (0.44) | PTK6AURKBLCKTTKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897839-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | claimed |
| WO-2020126952-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | claimed |
| EP-3897839-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020126952-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |