Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30171739 | 0.99 | TTK (0.46) | TTKMAPKAPK5IDO1BRAFPTK6 | |
| SCHEMBL22124726 | 0.93 | TTK (0.48) | TTKMAPKAPK5BRAFPTK6 | |
| Hydrochloric Acid SCHEMBL30171803 | 0.92 | TTK (0.47) | TTKMAPKAPK5BRAFPTK6 | |
| SCHEMBL22124666 | 0.92 | TTK (0.46) | TTKMAPKAPK5BRAFPTK6 | |
| SCHEMBL22124744 | 0.92 | TTK (0.45) | TTKMAPKAPK5BRAFPTK6 | |
| SCHEMBL22124765 | 0.91 | TTK (0.48) | TTKMAPKAPK5BRAFPTK6 | |
| Hydrochloric Acid SCHEMBL30171610 | 0.91 | TTK (0.45) | TTKMAPKAPK5BRAFPTK6 | |
| SCHEMBL22124837 | 0.91 | TTK (0.40) | TTKMAPKAPK5IDO1BRAFPTK6 | |
| SCHEMBL22124907 | 0.90 | TTK (0.46) | TTKMAPKAPK5BRAFPTK6 | |
| SCHEMBL22124704 | 0.90 | TTK (0.45) | TTKMAPKAPK5BRAFPTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | claimed |
| EP-3898630-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | claimed |
| WO-2020126954-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | claimed |
| EP-3898630-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020126954-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |