Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 6/20 | 0.39 |
| ▸ | TTK | P33981 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 9/20 | 0.34 |
| ▸ | JAK1 | P23458 | 9/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123777 | 0.94 | PTK6 (0.38) | PTK6TTKJAK2JAK1LCK | |
| SCHEMBL22124183 | 0.93 | PTK6 (0.40) | PTK6TTKJAK2JAK1AURKB | |
| Formic Acid SCHEMBL28607904 | 0.90 | PTK6 (0.39) | PTK6TTKJAK2JAK1AURKB | |
| SCHEMBL22124881 | 0.86 | PTK6 (0.39) | PTK6TTKAURKBLCKMAP3K7 | |
| SCHEMBL22123724 | 0.86 | PTK6 (0.39) | PTK6TTKJAK2JAK1AURKB | |
| SCHEMBL22142951 | 0.85 | PTK6 (0.40) | PTK6TTKJAK2JAK1AURKB | |
| SCHEMBL22123708 | 0.85 | PTK6 (0.38) | PTK6TTKJAK2JAK1AURKB | |
| SCHEMBL22154470 | 0.85 | PTK6 (0.41) | PTK6TTKAURKBLCK | |
| SCHEMBL24112413 | 0.84 | PTK6 (0.41) | PTK6TTKJAK2JAK1AURKB | |
| SCHEMBL22153130 | 0.84 | PTK6 (0.39) | PTK6TTKJAK2JAK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897839-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020126952-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |