Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16932061 | 1.00 | GAA (0.43) | GAAL3MBTL1RECQLNPY1RTP53 | |
| SCHEMBL4179661 | 1.00 | GAA (0.43) | GAAL3MBTL1RECQLNPY1RTP53 | |
| SCHEMBL22126565 | 1.00 | GAA (0.43) | GAAL3MBTL1RECQLNPY1RTP53 | |
| SCHEMBL26621560 | 0.86 | GAA (0.42) | GAAL3MBTL1RECQLTP53EPHX1 | |
| SCHEMBL22291056 | 0.86 | GAA (0.42) | GAAL3MBTL1RECQLTP53EPHX1 | |
| SCHEMBL22291055 | 0.86 | GAA (0.42) | GAAL3MBTL1RECQLTP53EPHX1 | |
| SCHEMBL4164968 | 0.85 | KDM4E (0.48) | L3MBTL1NPC1ALOX15ALDH1A1 | |
| SCHEMBL16459750 | 0.85 | KDM4E (0.48) | L3MBTL1NPC1ALOX15ALDH1A1 | |
| SCHEMBL4164966 | 0.85 | KDM4E (0.48) | L3MBTL1NPC1ALOX15ALDH1A1 | |
| SCHEMBL15507141 | 0.85 | KDM4E (0.48) | L3MBTL1NPC1ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11072619-B2 | Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors | CELON PHARMA S.A. (PL) | 2021-07-27 | — | — | US | disclosed |
| EP-3621966-B1 | PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS | Celon Pharma Sa (PL) | 2020-11-18 | — | — | EP | disclosed |
| US-20200199128-A1 | PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS | CELON PHARMA S.A. (PL) | 2020-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072619-B2 | Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors | JAK1, JAK3, JAK2 | GAA 4529/4885L3MBTL1 3047/4885RECQL 4174/4885 |
| US-20200199128-A1 | PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS | JAK1, JAK3, JAK2 | GAA 4529/4885L3MBTL1 3047/4885RECQL 4174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.