Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.62 |
| ▸ | RAF1 | P04049 | 8/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | PLK4 | O00444 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | FYN | P06241 | 3/20 | 0.51 |
| ▸ | LYN | P07948 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | AXL | P30530 | 3/20 | 0.51 |
| ▸ | FRK | P42685 | 3/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.51 |
| ▸ | BLK | P51451 | 3/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.51 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2212728 | 0.94 | MAPK14 (0.72) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL2209824 | 0.93 | MAPK14 (0.62) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL2210314 | 0.93 | MAPK14 (0.62) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL2212959 | 0.92 | MAPK14 (0.56) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL2213841 | 0.86 | MAPK14 (0.72) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL2214160 | 0.83 | MAPK14 (0.87) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL8737511 | 0.80 | RAF1 (0.60) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL12391532 | 0.79 | RAF1 (0.76) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL257980 | 0.77 | RAF1 (0.82) | BRAFMAPK14RAF1EPHX2KDR | |
| SCHEMBL2240951 | 0.77 | MAPK14 (0.66) | BRAFMAPK14RAF1EPHX2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866302-B1 | PYRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | claimed |
| US-7767696-B2 | Antitumor agents; tyrosine inhbitor; controllling kinase signal transduction | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | claimed |
| US-20080207699-A1 | Pyrazole Derivatives | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207699-A1 | Pyrazole Derivatives | TIE1, FER, RAF1 | BRAF 8/4885MAPK14 474/4885RAF1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.